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The Science Behind Our New Class of Medicine
Decades of pioneering research at Baylor College of Medicine revealed how the body's own repair systems can be reawakened. From understanding how genes are switched on to uncovering how cells heal under stress, each discovery built on the last and led to the development of Oxia's Endogenous Repair Modulators (ERM), a new class of medicine that helps the body repair itself from within.
Hormone Signaling | Dr Bert OMalley (2007 National Medal of Science Award)
Discovered how hormones communicate directly with DNA to control gene expression, unlocking the body's molecular
Steroid Receptor Coactivators (SRCs) | Dr. Bert O'Malley (2023 Cozzarelli Prize by PNAS)
Identified SRCs as vital amplifiers of hormone signaling and key regulators of gene expression.
Small Molecule Activator Synthesis | Dr. David Lonard, PhD
Developed the first small molecules to activate SRCs, showing that these powerful pathways could be pharmacologically targeted.
Precision Targeting via Cellular Signaling | Dr. Lisa McClendon, PhD
Revealed that SRCs direct the body's repair response to stress, injury, and hypoxia, leveraging the epigenetics of repair to deliver a transformative new class of medicine.
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We believe science begins with curiosity.
At Oxia, we begin with scientific curiosity. We are driven to understand how the body repairs itself and why that process sometimes fails. Our research seeks to reactivate those innate programs of recovery and transform knowledge into therapies that restore the body’s original design for healing.
Our Ethos
Oxia is built on a simple belief that the body already knows how to heal. Our work is focused on reawakening that natural intelligence and turning it into meaningful recovery for patients. The pillars below reflect what drives us every day: bold curiosity, purposeful collaboration, and a commitment to restoring health in a way that feels both possible and transformational.
Together, we move science forward.
Collaboration fuels every breakthrough we make. Our scientists, clinicians, and partners work together across disciplines to uncover new ways of activating the body’s natural repair system. Together, we are advancing a new generation of medicine focused on restoration, not replacement.
Our purpose begins with patients.
Patients gives our science meaning. We believe healing should not be exceptional. It should be expected. Our discoveries aim to restore health, resilience, and hope for people everywhere.